Public health alert: rising teen overdoses from Diphenhydramine
Washington Poison Center has identified a concerning and sustained increase in overdoses among youth involving diphenhydramine, a common over-the-counter medication (brand name BenadrylTM). This trend is linked to both intentional self-harm and substance misuse. Coordinated action across healthcare providers, schools, and community organizations is essential to reduce harm and prevent further increases.
Diphenhydramine is found in many over-the-counter sleep aids, cough and cold medications, and allergy medications. It is safe when used as directed, but taking large amounts can be dangerous and potentially life-threatening.
In 2025, Washington Poison Center treated an average of 32 cases/month of adolescents ages 13 to 19 years with diphenhydramine exposures. In the first three months of 2026, however, there has been an average of 52 cases/month. Diphenhydramine overdoses currently account for approximately 10% of all cases in this age group, up from 5% in 2024.